The kidney is the innate foundation of the human body and is in charge of the Yuan Yin and Yuan Yang of the human body. It plays a very important role in human growth and development, essence and blood metaplasia, body fluid circulation, receiving Qi and regulating breath, generating ambition and wisdom. Especially in regulating essence, blood and water. We treat reproductive system diseases, blood system diseases and fluid circulation diseases through the regulation of the kidney on essence, blood and water. We have some clinical cases to illustrate its operability and effectiveness by this way.